INO80 subfamily of chromatin remodeling complexes
نویسندگان
چکیده
منابع مشابه
SnapShot: Chromatin Remodeling: INO80 and SWR1
The INO80 and SWR1 complexes belong to the INO80 subfamily of ATP-dependent chromatin-remodeling complexes. These complexes interact with nucleosomes and remodel chromatin by either sliding nucleosomes along the DNA or exchanging histones within nucleosomes. In doing so, the INO80 and SWR1 complexes promote recruitment of regulatory factors to DNA. Distinct from other subfamilies of chromatin-r...
متن کاملIno80 Chromatin Remodeling Complex Promotes Recovery of Stalled Replication Forks
BACKGROUND Chromatin remodeling complexes facilitate the access of enzymes that mediate transcription, replication or repair of DNA by modulating nucleosome position and/or composition. Ino80 is the DNA-dependent Snf2-like ATPase subunit of a complex whose nucleosome remodeling activity requires actin-related proteins, Arp4, Arp5 and Arp8, as well as two RuvB-like DNA helicase subunits. Budding...
متن کاملDistinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.
INO80 and SWR1 are two closely related ATP-dependent chromatin remodeling complexes that share several subunits. Ino80 was reported to be recruited to the HO endonuclease-induced double-strand break (DSB) at the budding yeast mating-type locus, MAT. We find Swr1 similarly recruited in a manner dependent on the phosphorylation of H2A (gammaH2AX). This is not unique to cleavage at MAT; both Swr1 ...
متن کاملFunction of the INO80 chromatin remodeling complex in DNA replication.
ATP-dependent chromatin remodeling complexes are involved in several nuclear processes. In particular the INO80 remodeling complex is an essential factor during transcription and DNA repair. Recently, several labs have described a novel role for INO80 during DNA replication. Moreover, Falbo et al. have presented evidence linking INO80's activities to the DNA damage tolerance pathways during rep...
متن کاملSnapShot: Chromatin Remodeling Complexes
Unique subunits Swp82, Taf14, Snf6, Snf11 Rsc3,5,7,9, 10,30, Htl1, Ldb7, and Rtt102 INO80 regulates transcription and is involved in DNA repair and cellcycle checkpoint adaptation. It has ATP-dependent nucleosome mobilization activity in vitro. SWR1 regulates transcription and is also involved in deposition of histone H2AZ, chromosome stability, and cell-cycle checkpoint adaptation. In vitro it...
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ژورنال
عنوان ژورنال: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
سال: 2007
ISSN: 0027-5107
DOI: 10.1016/j.mrfmmm.2006.10.006